NEOPLURAMYCIN, AN INHIBITOR OF NUCLEIC ACID SYNTHESIS
نویسندگان
چکیده
منابع مشابه
Nucleic Acid Synthesis
INTRODUCTION Synthesis in the field of nucleic acids has been a major and continuing interest in my laboratory ever since we knew the structures of the nucleic acids. Clearly the foundations of synthetic work in the nucleotide field were laid by the prolonged and intensive efforts of Professor Todd's laboratory (Cambridge, England) and it was my good fortune to be associated with this laborator...
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1. The antibiotic lomofungin was found to be a potent inhibitor of both DNA and RNA synthesis in Saccharomyces cerevisiae. Underselected growth conditions inhibition ofDNA synthesis by the drug preceded inhibition of RNA synthesis. 2. Although in general lomofungin inhibited synthesis ofribosomalRNA and polydisperseRNA more effectively than that of low-molecular-weight RNA, under certain condit...
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1. Mycophenolic acid, an antibiotic of some antiquity that more recently has been found to have marked activity against a range of tumours in mice and rats, strongly inhibits DNA synthesis in the L strain of fibroblasts in vitro. 2. The extent of the inhibition of DNA synthesis is markedly increased by preincubation of the cells with mycophenolic acid before the addition of [(14)C]thymidine. 3....
متن کاملInhibition of Nucleic Acid Synthesis by Folie Acid Antagonists*
Woolley and Pringle (13) have recently reported the formation of 4-amino-5-carboxamidoimidazole during growth of Escherichia coli in the presence of 4-aminopteroylglutainic acid (aminopterin). Some of us have observed that excessive doses of folie acid speed up the leukemic process in mice and that folie acid will reverse the well known antileukemic action of aminopterin (11). This reversal of ...
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Woolley and Pringle (13) have recently reported the formation of 4-amino-5-carboxamidoimidazole during growth of Escherichia coli in the presence of 4-aminopteroylglutainic acid (aminopterin). Some of us have observed that excessive doses of folie acid speed up the leukemic process in mice and that folie acid will reverse the well known antileukemic action of aminopterin (11). This reversal of ...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1971
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.24.189